Tick-borne infections

Clinical information

Ticks can transmit different viral, bacterial and parasitic infectious agents to a person during blood feeding. Alongside Borrelia, which causes Lyme borreliosis, the most frequent tick-borne disease in the northern hemisphere, the range of pathogens include TBE virus, Crimean-Congo fever virus, Anaplasma, Rickettsia, Babesia, Ehrlichia and Coxiella. Depending on the pathogen, tick-borne infections may lead to various clinical symptoms, with involvement of, for example, the skin, joints, muscles, inner organs and central nervous system. Disease courses range from asymptomatic or subclinical to severe and life-threatening. Since there are only vaccines to some of the tick-borne pathogens, exposition prophylaxis is the most effective protection measure. 

Diagnostics

Laboratory diagnostics of tick-borne infections are based on direct and indirect detection methods. Direct procedures include e.g. blood smears, pathogen cultures or PCR-based tests, while indirect detection is mainly based on the detection of specific antibodies against the respective pathogen in patient serum, plasma or CSF. Detection of antibodies is the most important laboratory diagnostic method in cases where it is difficult to obtain suitable sample materials for direct detection, or the amount of pathogen in the sample is too low. For antibody determination in cases of suspected tick-borne infection, EUROIMMUN offers a wide range of serological test systems, including ELISAs, ChLIAs, immunofluorescence tests (IIFT), immunoblots and EUROMicroblots, miniaturised immunoblots in microplate format.

Files

Differentiated Borrelia diagnostics

Professional article in Forum Sanitas: Diagnostic Workup and Treatment of Lyme Disease

EUROMicroblot - Efficient blot technology for high throughput

 

 Learn more about the technology and automated processing of the
 EUROMicroblots in this video.

 

Techniques

Method
Parameter
Substrate
Species
EUROLINE
EUROLINE Borrelia-RN-AT
(p18, p19, p20, p21, p58,
OspC (p25), p39, p83, LBb, LBa,
VlsE Bg, VlsE Bb, VlsE Ba separately)
EUROLINE
EUROLINE
EUROLINE Borrelia-RN-AT
(OspC Bg native, OspC Bb native,
OspC Ba native, p39, VlsE Bb separately)
EUROLINE
EUROLINE
positive control serum: IgG, human, 50x concentrated
for Borrelia
WESTERNBLOT
Borrelia afzelii
Westernblot
EUROLINE
positive control serum: IgM, human, 50x concentrated
for Borrelia
WESTERNBLOT
antibodies against Borrelia afzelii
IgG positive control
(Westernblot/EUROLINE-WB)
WESTERNBLOT
antibodies against Borrelia afzelii
IgM positive control
(Westernblot/EUROLINE-WB)
MICROBLOT
EUROMicroblot Anti Borrelia (IgG)
MICROBLOT
EUROMicroblot Anti Borrelia (IgM)
WESTERNBLOT
EUROLINE-WB
Borrelia
Westernblot
EUROLINE
EUROLINE Borrelia-RN-AT-adv
(OspC-adv Bsp, OspC-adv Bg, OspC-adv
Bb, OspC-adv Ba, p39, VlsE Bb separately)
EUROLINE
ChLIA
IDS Borrelia Burgdorferi Control Set
3 x 1.5mL Control 1/2
WESTERNBLOT
Borrelia burgdorferi
Westernblot
ChLIA
IDS Borrelia Burgdorferi IgG

antigenic coated magnetic particles
ChLIA
IDS Borrelia Burgdorferi IgM

antigenic coated magnetic particles
ChLIA
Control set Anti-Borrelia ChLIA (IgG) 
2 x 0.5 ml control 1/2
ChLIA
Control set Anti-Borrelia ChLIA (IgM) 
2 x 0.5 ml control 1/2
WESTERNBLOT
antibodies against Borrelia burgdorferi
IgG positive control
ELISA
Borrelia
incl. IgG/RF absorbent
antigen-coated
microplate wells
ChLIA
Anti-Borrelia ChLIA (IgG) 
Antigen-coated magnetic particles
ChLIA
Anti-Borrelia ChLIA (IgM) 
Antigen-coated magnetic particles
WESTERNBLOT
antibodies against Borrelia burgdorferi
IgM positive control
ELISA
Borrelia
plus VlsE
antigen-coated
microplate wells
ELISA
Lyme ELISA
antigen-coated
microplate wells
ELISA
Borrelia Select: recombinant
antigens with VlsE
antigen-coated
microplate wells
ELISA
Borrelia Select: recombinant
antigens with OspC advanced
antigen-coated
microplate wells
ELISA
CSQ pair of controls
anti-Borrelia (IgG)
ELISA
CSQ pair of controls
anti-Borrelia (IgM)
ELISA
Borrelia PLUS VlsE
antibody determination in CSF
antigen-coated
microplate wells
ELISA
Borrelia
antibody determination in CSF
antigen-coated
microplate wells
WESTERNBLOT
Borrelia garinii
Westernblot
WESTERNBLOT
Borrelia garinii
Westernblot
WESTERNBLOT
antibodies against Borrelia garinii
IgG positive control
WESTERNBLOT
antibodies against Borrelia garinii
IgM positive control
IIFT
EUROPLUS
Borrelia afzelii
Borrelia burgdorferi (USA)
OspC antigen
VlsE antigen
4 BIOCHIPs per field:
bacterial smear
bacterial smear
OspC BIOCHIPs
VlsE BIOCHIPs

B. afzelii
B. burgd. (USA)
B. burgdorferi
recombinant
ELISA
Coxiella burnetii phase 1
antigen-coated
microplate wells
ELISA
Coxiella burnetii phase 2
antigen-coated
microplate wells
IIFT
TBE virus (TBEV)
infected and non-
infected cells
(2 BIOCHIPs per field)
EU 14
ELISA
TBE virus
incl. IgG/RF absorbent
antigen-coated
microplate wells
IIFT
Flavivirus Mosaic 1
TBE virus (TBEV)
West Nile virus (WNV)
Japanese encephalitis virus (JEV)
Yellow fever virus (YFV)
4 BIOCHIPs per field:
infected cells
infected cells
infected cells
infected cells

EU 14
EU 14
EU 14
EU 14
IIFT
Flavivirus Profile 2
upper row:
TBE virus (TBEV)
West Nile virus (WNV)
Japanese encephalitis virus (JEV)
Yellow fever virus (YFV)
bottom row:
Dengue virus
types 1 - 4 (DENV)


infected cells
infected cells
infected cells
infected cells

infected cells


EU 14
EU 14
EU 14
EU 14

EU 14
ELISA
Anti-TBE Virus ELISA 2.0 (IgG)
antigen-coated
microplate wells
ELISA
Anti-TBE Virus CSF ELISA 2.0 (IgG)
antigen-coated
microplate wells
ELISA
CSQ pair of controls
anti-TBE virus Vienna (IgG)
ELISA
CSQ pair of controls
anti-TBE virus (IgG)
ELISA
CSQ pair of controls
anti-TBE virus (IgM)
ELISA
TBE virus
antibody determination in CSF
antigen-coated
microplate wells
ELISA
Crimean Congo fever virus
(CCHFV)
antigen-coated
microplate wells
ELISA
Crimean Congo fever virus
(CCHFV) incl. IgG/RF absorbent
antigen-coated
microplate wells
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